ELISA Substrates and Reagents
ABclonal Technology Phospho-PPP1R12A-T853 Rabbit pAb
Myosin phosphatase target subunit 1 (MBS), also known as the myosin-binding subunit, is part of myosin phosphatase, which regulates actin-myosin interaction through Rho GTPases. RhoA, in its active GTP-bound form, interacts with MBS to control myosin light chain (MLC) phosphorylation, affecting smooth muscle contraction and actin-myosin interaction in nonmuscle cells. Rho-kinase, activated by RhoA, phosphorylates MBS, inhibiting myosin phosphatase. Overexpression of RhoA increases MBS and MLC phosphorylation. This protein plays a key role in regulating actin dynamics. Multiple transcript variants encoding distinct isoforms have been identified.
ABclonal Technology Phospho-DDR1-Y792 Rabbit pAb
Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
ABclonal Technology Phospho-PPP1R12A-S668 Rabbit pAb
Myosin phosphatase target subunit 1 (MBS) is a subunit of myosin phosphatase, which regulates the actin-myosin interaction downstream of the GTPase Rho. RhoA, in its active GTP-bound form, interacts with MBS to control myosin light chain (MLC) phosphorylation, affecting smooth muscle contraction and nonmuscle cell function. RhoA activates Rho-kinase, which phosphorylates MBS and inactivates myosin phosphatase. Overexpression or activation of RhoA increases MBS and MLC phosphorylation. This pathway regulates the balance of actin and myosin interaction. Several isoforms of this gene have been identified due to alternative splicing.
Cayman Chemical para-fluoro Phenthyl 4-nPP 5mg
An analytical reference standard that is structurally similar to known opioids; intended for research and forensic applications
American Research Products Inc Rat urokinase plasminogen acti
Rat urokinase plasminogen actiVator uPA ELISA kit from CUSABIO Detection Range 15 6 pg/mL-1000 pg/mL Sensitivity 3 9 pg/mL Sample serum plasma tissue homogenates Method Sandwich
ABclonal Technology HYAL1 Rabbit mAb
This gene encodes a lysosomal hyaluronidase Hyaluronidases intracellularly degrade hyaluronan one of the major glycosaminoglycans of the extracellular matrix Hyaluronan is thought to be involved in cell proliferation migration and differentiation This enzyme is active at an acidic pH and is the major hyaluronidase in plasma Mutations in this gene are associated with mucopolysaccharidosis type IX or hyaluronidase deficiency The gene is one of several related genes in a region of chromosome 3p21 3 associated with tumor suppression Multiple transcript variants encoding different isoforms have been found for this gene
Aat Bioquest ReadiUse™ ABTS Substrate Solution *Optimized for ELISA Assays with HRP Conjugates*
Horseradish peroxidase (HRP) and HRP conjugates facilitate the ABTS oxidation in the presence of hydrogen peroxide, turning ABTS into its blue-green oxidized product. This chromogenic reaction is widely used for quantify HRP in ELISA assays.
Zymo Research Corporation Control E (100 ng/ul) (40 ul)
Control E DNA (100 ng/µl) (40 µl) for use with Quest 5-hmC DNA ELISA Kit for DNA hydroxymethylation detection and quantification.
ABclonal Technology Phospho-HSP27/HSPB1-S78 Rabbit pAb
This gene encodes a member of the small heat shock protein (HSP20) family of proteins. In response to environmental stress, the encoded protein translocates from the cytoplasm to the nucleus and functions as a molecular chaperone that promotes the correct folding of other proteins. This protein plays an important role in the differentiation of a wide variety of cell types. Expression of this gene is correlated with poor clinical outcome in multiple human cancers, and the encoded protein may promote cancer cell proliferation and metastasis, while protecting cancer cells from apoptosis. Mutations in this gene have been identified in human patients with Charcot-Marie-Tooth disease and distal hereditary motor neuropathy.
ABclonal Technology Phospho-ACC1-S79 Rabbit pAb
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5 sequence and encoding distinct isoforms have been found for this gene.